Unofficial Skyrim Patch - a comprehensive bugfixing mod also contains a 'savegame debloatifier' feature that may help improve performance
THIS WILL NOT DEGRADE QUALITY IN ANY WAY TO INCREASE PERFORMANCE. THIS IS NOT A GRAPHIC MODIFICATION, so feel free to use with vanilla game. Have you tired from CTDs when your game is heavily modded? Unable to install HD texture packs without CTDs or travel in the world very fast? This patch fixes the problem and also brings you higher performance even without memory fixes enabled. Some mods or software that you could use to increase performance: